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Status of Lipid Peroxidation, Antioxidants, and Oxidation Products of Nitric Oxide in Equine Babesiosis: Status of Antioxidant and Oxidant in Equine Babesiosis
Authors:Serdar Deger PhD  VMD  Prof Dr  Yeter Deger PhD  VMD  Assoc Prof Dr  Kamile Bicek PhD  VMD  Assoc Prof Dr  Nalan Ozdal PhD  VMD  Asst Prof Dr  Abdurrahman Gul PhD  VMD  Assoc Prof Dr
Institution:aDepartment of Parasitology, Faculty of Veterinary Medicine, University of Yuzuncu Yıl, Van, Turkey;bDepartment of Biochemistry, Faculty of Veterinary Medicine, University of Yuzuncu Yıl, Van, Turkey
Abstract:Equine babesiosis is a tick-borne protozoal disease of horses caused by Theileria equi and Babesia caballi. The disease is endemic in most tropical and subtropical areas. The aim of this paper is to assess the antioxidant status, lipid peroxidation, and oxidation products of nitric oxide (NO) in horses and mules naturally infected with T. equi and B. caballi. East and Southeast Anatolian horses and mules living in rural region of the Eastern border of Turkey were used as the material for this study. These animals are used as pack animal (3–7 years of age). Infected animals were in acute or subacute infection period. In the current study, malondialdehyde (MDA), oxidation products of NO (nitrate and nitrite), serum glutathione (GSH), vitamin E, and retinol levels were analyzed in 58 equids (horse and mule) infected with T. equi and B. caballi as well as in 44 healthy equids. Compared with controls, the level of MDA and nitrate increased significantly (P < .01, P < .05, respectively), whereas GSH concentration and levels of vitamin E decreased significantly (P < .01). There was no significant change in the level of nitrite and retinol between two groups. The results of the current study suggest that in equids infected with T. equi and B. caballi, this alteration in the lipid peroxidation, oxidants, and antioxidants may be related to the host's defenses against parasitic infection and may play a central role in the pathologic conditions associated with babesiosis.
Keywords:Equine babesiosis  Malondialdehyde  Oxidation products of NO  Glutathione  Vitamins
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