| 雄激素对大鼠垂体中AR蛋白表达的影响 |
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| 引用本文： | 李定强等.雄激素对大鼠垂体中AR蛋白表达的影响[J].中国农学通报,2005,21(12):8-8. |
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| 作者姓名： | 李定强等 |
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| 作者单位： | 西北农林科技大学动物科技学院,陕西,杨凌,712100 |
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| 基金项目： | 国家自然科学基金项目“中枢神经系统突触素表达的形态机能研究”（39670550）、陕西省自然科学基金“神经生长因子对下丘脑神经内分泌细胞的影响”（2000SM04）、西北农林科技大学2005年大学生课外学术科技学术作品基金“雄激素受体在大鼠垂体中的表达及雄激素对其的调节研究”（KWX05043）. |
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| 摘 要： | 利用免疫组化SP法检测去势及补充雄激素后大鼠垂体中雄激素受体(Androgen Receptor,AR)蛋 白的表达,以探讨雄激素对垂体的作用机制。结果表明:去睾丸组(GM组)大鼠垂体AR减少;去睾丸并 补充雄激素组(GM T组)大鼠AR表达恢复到接近正常水平。说明去睾丸大鼠由于缺乏内源性雄激素 引起垂体AR表达减少;而补充外源性雄激素可缓解或抑制这一变化。
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| 关 键 词： | 去睾丸 雄激素受体 雄激素 |
| 收稿时间： | 2005-07-09 |
| 修稿时间： | 2005-07-092005-07-13 |
Effects of Testosterone on AR of Pitutary in Rat |
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| Li Dingqiang,Tian Guangming,Wang Guankui,Fan Guangli.Effects of Testosterone on AR of Pitutary in Rat[J].Chinese Agricultural Science Bulletin,2005,21(12):8-8. |
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| Authors: | Li Dingqiang Tian Guangming Wang Guankui Fan Guangli |
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| Institution: | Collage of Animal Science and Technology, Northwest Sci-Tech University of Agrlculture and Forestry, Yangling Shaanxi 712100 |
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| Abstract: | Use the method of immunochemistry SP to study the AR positive expression of rats to investigate the effects of androgen replacement on pitutary. As the result, contrast with the control group, in castration group, the positive expression of AR were decreased. After treated with testosterone, the immunoreactive production of AR were increased and immunoreactive production of AR almost returned to the normal level. All the results illustrated that the expression of AR were decreased after castration, and the testosterone can prevent this results by down regulating the expression of AR and NGF. |
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| Keywords: | Castration AR Testosterone |
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