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Impact of lactation on pharmacokinetics of meloxicam in goats
Authors:Tae-Won Kim  Irene Sartini  Beata ?ebkowska-Wieruszewska  Andrzej Lisowski  Amnart Poapolathep  Mario Giorgi
Institution:1. Department of Veterinary Medicine & Institute of Veterinary Science, Chungnam National University, Daejeon, Korea;2. Department of Veterinary Medicine, University of Sassari, Sassari, Italy;3. Department of Pharmacology, University of Life Sciences, Lublin, Poland;4. Institute of Animal Breeding and Biodiversity Conservation, University of Life Sciences, Lublin, Poland;5. Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand;6. Department of Veterinary Sciences, University of Pisa, Pisa, Italy
Abstract:Use of drug in lactating animal should be carefully considered due to its possibility of changes in pharmacokinetics as well as drug penetration in milk. The aim of this study was to assess the effect of lactation on pharmacokinetics of meloxicam after IV and IM administrations in goats. A crossover design (2 × 2) was used for each lactating and nonlactating group of goats with a 3-week washout period. Meloxicam (0.5 mg/kg) was administered into the jugular vein and upper gluteal muscle by IV and IM routes, respectively. The plasma and milk drug concentrations were determined by high-performance liquid chromatography with diode array detector, and the pharmacokinetic analysis was carried out by noncompartmental analysis. The pharmacokinetic parameters of meloxicam in lactating and nonlactating goats were not significantly different. The IM bioavailability of meloxicam was relatively lower in lactating (75.3 ± 18.6%) than nonlactating goats (103.8 ± 34.7%); however, the difference was not statistically significant. Moreover, AUC ratio between milk and plasma, which represent drug milk penetration, for both IV and IM administrations was less than 1 (about 0.3). In conclusion, pharmacokinetic parameters of meloxicam are not significantly altered by lactation for either the IV or IM routes of administration and this drug does not require a different dosage regimen for lactating animals.
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