药物脱绒对辽宁绒山羊血清激素及酶水平的影响

将12只4岁雌性健康辽宁绒山羊，随机分为4组，分别为对照组、埋植褪黑素（每只60 mg）组、埋植褪黑素（每只60 mg）+注射环磷酰胺（26 mg·kg-1）组及注射环磷酰胺（26 mg·kg-1）组，分别于试验开始后0、30和50 d采样，检测血清激素及酶水平，以分析药物脱绒对辽宁绒山羊血清激素及酶水平的影响。结果表明，褪黑素可提升辽宁绒山羊血清α 淀粉酶（A AMY）、碱性磷酸酶（ALP）的水平，降低肾上腺皮质激素（ACTH）、皮质醇（Cor）、表皮生长因子（EGF）、血清肌酸磷酸激酶(CPK)的含量；环磷酰胺可提升CPK、A AMY、Cor的水平，降低碱性磷酸酶（ALP）、褪黑素（MT）的含量。说明，埋植褪黑素可以在一定程度上降低环磷酰胺脱毛引起的应激反应。

Effects of depilation by drugs on serum hormone and enzyme levels of Liaoning Cashmere goat

This study was to examine effects of depilation by drugs on blood hormone and enzyme levels of Liaoning Cashmere goat.Twelve four-year-old female Liaoning Cashmere goats were divided into four groups randomly,in which control group was without any treatment,groupⅠ was treated with subcutaneous implantation of melatonin(60 mg·goat-1),groupⅡ was subcutaneous implantation of melatonin plus injected muscularly with cyclophosphamide(26 mg·kg-1),and groupⅢ was only injected with cyclophosphamide(26 mg·kg-1).To determine the levels of several serum hormones and enzymes,blood samples of goats were collected and tested at 0,30 and 50 d after treatments.Results obtained from the study showed that subcutaneous implantation of melatonin increased the levels of alpha amylase(A-AMY) and alkaline phosphatase(ALP),but reduced the levels of adrenocorticotrophic hormone(ACTH),cortisol(Cor),epidermal growth factor(EGF) and creatine phosphokinase(CPK).Injection of the cyclophosphamide increased the levels of creatine phosphokinase,alpha amylase and cortisol,and reduced the levels of alkaline phosphatase and melatonin(MT).