Electrospinning of fucoidan/chitosan/poly(vinyl alcohol) scaffolds for vascular tissue engineering |
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Authors: | Weijie Zhang Lei Zhao Jianzhong Ma Xiaochun Wang Yonggang Wang Fen Ran Yanling Wang Hui Ma Shujing Yu |
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Institution: | 1.School of Life Science and Engineering,Lanzhou University of Technology,Lanzhou, Gansu,China;2.School of Materials Science and Engineering,Lanzhou University of Technology,Lanzhou, Gansu,China;3.Pathology Department,Wuqiang County Hospital,Wuqiang County, Hebei,China |
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Abstract: | The formation of thrombosis has limited the applications of small diameter vascular in cardiovascular diseases. In order to improve the anticoagulant activities of scaffolds, this study combined fucoidan with CS/PVA and investigated the complete physicochemical and mechanical characterization of the scaffolds to evaluate the feasibility of Fucoidan/CS/PVA scaffolds used in vascular tissue engineering. The SEM graphs show a well defined and interconnected pore structure and the nanofiber diameters are ranging from 341 nm to 482 nm. After immersing in PBS for 5 days, the tensile strength of the crosslinked scaffolds was 722±38 kPa while the elongation at break was 35.5±1.6 %. Besides, added with fucoidan, the scafflolds showed lower rate of plate adhesion (14.75±2.10 %) and markedly prolonged the APTT and TT. Furthermore, owing to the great water uptake ability, sufficient porosity, enhanced drug release and low cytotoxicity, the Fucoidan/CS/PVA scaffolds might be used for vascular tissue engineering with good prospect. |
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