| 苯甲酰脲类化合物的合成及杀虫活性 |
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| 引用本文： | 张文文,郑震,彭延庆,徐晓勇,李忠. 苯甲酰脲类化合物的合成及杀虫活性[J]. 农药学学报, 2009, 11(1): 36-40 |
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| 作者姓名： | 张文文 郑震 彭延庆 徐晓勇 李忠 |
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| 作者单位： | 上海市化学生物学重点实验室,华东理工大学,药学院,上海,200237;上海市化学生物学重点实验室,华东理工大学,药学院,上海,200237;上海市化学生物学重点实验室,华东理工大学,药学院,上海,200237;上海市化学生物学重点实验室,华东理工大学,药学院,上海,200237;上海市化学生物学重点实验室,华东理工大学,药学院,上海,200237 |
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| 基金项目： | 国家自然科学基金，上海市科委和教委资助项目 |
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| 摘 要： | 对2-氨基-5-芳基-1,3,4- 口 恶 二唑的合成进行了深入研究,找到了一种基于HBr-H2O2 体系的绿色合成新方法,并以此为中间体,合成了18个未见报道的苯甲酰脲类目标化合物,所有化合物均通过核磁共振、高分辨质谱、红外光谱的分析鉴定。生物活性测试结果表明,在500 mg/L浓度下该系列目标化合物均未表现出显著的杀虫活性。
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| 关 键 词： | HBr-H2O2溴代体系 绿色合成 苯甲酰脲 昆虫生长调节剂 |
| 收稿时间： | 2008-12-20 |
Synthesis and Insecticidal Activity of Benzoylphenylurea Derivatives |
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| ZHANG Wen-wen,ZHENG Zhen,PENG Yan-qing,XU Xiao-yong and LI Zhong. Synthesis and Insecticidal Activity of Benzoylphenylurea Derivatives[J]. Chinese Journal of Pesticide Science, 2009, 11(1): 36-40 |
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| Authors: | ZHANG Wen-wen ZHENG Zhen PENG Yan-qing XU Xiao-yong LI Zhong |
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| Affiliation: | 1.Shanghai Key Lab of Chemical Biology,School of Pharmacy,East China Universityof Science and Technology,Shanghai 200237,China |
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| Abstract: | A cleaner approach to 2-amino-5-aryl-1,3,4-oxadiazoles,a series of benzoylphenylurea intermediates were developed and optimized by using HBr-H2O2 system as an alternative to molecular bromine.Eighteen novel benzoylphenylurea compounds were synthesized starting from 2-amino-5-aryl-1,3,4-oxadiazoles,and were identified by 1H NMR,HRMS and IR spectra.However,no remarkable insecticidal activity was observed during bioassay. |
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| Keywords: | H2O2/HBr bromination system green synthesis benzoylurea insect growth regulator |
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