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From sequence to chromosome: the tip of the X chromosome of D. melanogaster |
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| Authors: | Benos P V Gatt M K Ashburner M Murphy L Harris D Barrell B Ferraz C Vidal S Brun C Demailles J Cadieu E Dreano S Gloux S Lelaure V Mottier S Galibert F Borkova D Minana B Kafatos F C Louis C Sidén-Kiamos I Bolshakov S Papagiannakis G Spanos L Cox S Madueño E de Pablos B Modolell J Peter A Schöttler P Werner M Mourkioti F Beinert N Dowe G Schäfer U Jäckle H Bucheton A Callister D M Campbell L A Darlamitsou A Henderson N S McMillan P J Salles C Tait E A Valenti P Saunder R D Glover D M |
| Institution: | The European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton Hall, Cambridge CB10 1SD, UK. |
| Abstract: | One of the rewards of having a Drosophila melanogaster whole-genome sequence will be the potential to understand the molecular bases for structural features of chromosomes that have been a long-standing puzzle. Analysis of 2.6 megabases of sequence from the tip of the X chromosome of Drosophila identifies 273 genes. Cloned DNAs from the characteristic bulbous structure at the tip of the X chromosome in the region of the broad complex display an unusual pattern of in situ hybridization. Sequence analysis revealed that this region comprises 154 kilobases of DNA flanked by 1.2-kilobases of inverted repeats, each composed of a 350-base pair satellite related element. Thus, some aspects of chromosome structure appear to be revealed directly within the DNA sequence itself. |
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