猪肠上皮紧密连接蛋白研究进展

紧密连接是肠上皮细胞间的主要连接方式,对维持猪肠道黏膜上皮机械屏障和通透性起着重要作用。紧密连接蛋白是构成肠道黏膜屏障、决定肠壁通透性的重要蛋白质分子,对紧密连接的组成和功能发挥有很大影响。其中,ZO-1(zonula occludens 1)、Occludin(OCLN)和Claudins(CLDN)是构成细胞间紧密连接的重要蛋白分子,在维持细胞极性和紧密连接屏障功能方面起着重要作用。文章综述了ZO-1、Occludin和Claudins等猪紧密连接蛋白的结构、生物学功能以及基因表达情况,并对近年来这些蛋白的研究进展进行归纳总结,为进一步研究猪紧密连接相关蛋白的功能,寻找腹泻和肠道炎症等疾病的治疗方案提供一定的理论基础。

Research progress of intestinal epithelial tight junction proteins in piglets

Tight junction (TJ) is the main connection form between intestinal epithelial cells. It plays an important role in maintaining intestinal epithelial mechanical barrier and permeability of pig intestinal mucosa. The tight junction proteins are important protein molecules that form the intestinal mucosal barrier and determine the permeability of the intestinal wall, which have a great influence on the composition and function of the tight junctions. Among these proteins, zonula occludens 1 (ZO-1), Occludin (OCLN) and Claudins (CLDN) are the main components of the tight junctions, involving in maintaining the function of cell polarity and tight junction barrier. This review summarized the structure, biological functions and gene expression of tight junction proteins of ZO-1, Occludin and Claudins, then further offered an overview of the recent advances of these proteins for providing theoretical basis for further elucidating the functions of porcine tight junction-related proteins and developing treatment for diseases such as diarrhea and intestinal inflammation.