| 液相色谱-串联质谱法测定动物尿液中糖皮质激素类药物 |
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| 引用本文： | 韩立,宋善道,李华岑,刘素梅,班付国,宋志超. 液相色谱-串联质谱法测定动物尿液中糖皮质激素类药物[J]. 中国兽药杂志, 2011, 45(5) |
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| 作者姓名： | 韩立 宋善道 李华岑 刘素梅 班付国 宋志超 |
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| 作者单位： | 河南省兽药监察所,郑州,450008 |
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| 摘 要： | 建立了动物尿液样品中泼尼松(Prednisone)、泼尼松龙(Prednisolone)、甲基泼尼松龙(Methylprednisone)、地塞米松(Demxamethasone)、倍他米松(Betamethasone)、倍氯米松(Beclometasone)、醋酸氟氢可的松(Fludrocortisone Acetate)、醋酸可的松(Cortisone Acetate)、氢化可的松(Hydrocortisone)等9种糖皮质激素类药物的测定方法,明确规定了适用范围、确定了取样量、酶解、提取净化等方法以及液相色谱条件、串联质谱条件等.该方法具有较好的灵敏度、准确度和精密度.
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| 关 键 词： | 尿液 糖皮质激素 液相色谱-串联质谱 |
Detection Method of Glucocorticoid in Urine Sample by LC-MS/MS |
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| HAN Li,SONG Shan-dao,LI Hua-cen,LIU Su-mei,BAN Fu-guo,SONG Zhi-chao. Detection Method of Glucocorticoid in Urine Sample by LC-MS/MS[J]. Chinese Journal of Veterinary Drug, 2011, 45(5) |
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| Authors: | HAN Li SONG Shan-dao LI Hua-cen LIU Su-mei BAN Fu-guo SONG Zhi-chao |
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| Affiliation: | HAN Li,SONG Shan-dao,LI Hua-cen,LIU Su-mei,BAN Fu-guo,SONG Zhi-chao(Institute of Henan Veterinary Drug Contral,Zhengzhou 450008,China) |
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| Abstract: | This paper studied the detection method of nine kinds of glucocorticoid(prednisone,prednisolone,methylprednisone,demxamethasone,betamethasone,beclometasone,fludrocortisone acetate,cortisone acetate and hydrocortisone)in urine using liquid chromatographic-tandem mass spectrometry method,defined the sphere of application,determined the sampling quantity,purification,extraction method,liquid chromatography and tandem mass spectrometry conditions.It showed that this method has good sensitivity,accuracy and prec... |
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| Keywords: | urine glucocorticoid liquid chromatographic-tandem mass spectrometry |
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