猪链球菌对大环内酯类药物耐药性研究进展

随着养猪业的迅速发展,猪链球菌病也在世界范围内广泛传播。大环内酯类药物在养猪业中的广泛应用也使其耐药性随之产生,国内外猪链球菌对大环内酯类的耐药性较严重,耐药率达50%以上。目前国内外已报道的猪链球菌对大环内酯类耐药基因包括ermA、ermB、ermC和mefA,其中最常见的是ermB基因编码的内在型（cMLSB）耐药。大环内酯类耐药性特点表现为多重耐药株（MDR）占很大比例且与菌株血清型之间可能存在相关性。耐药基因erm及mef均为获得性耐药基因,位于转座子内,或由质粒携带,可在细菌间广泛传播。合理使用抗菌药物,加强耐药性监测,开发新药以及疫苗等对于减缓耐药性的产生和传播具有十分重要的意义。

Progress on the Resistance of Streptococcus suis Against Macrolides

With the development of pig husbandry, streptococcal disease of swine is spreading all over the world. The general usage of macrolides in cultivation of pigs leads to severe resistance of Streptococcus suis against macrolides, and the rate of resistance is in excess of 50%.At present, the reportorial drug-resistance genes include ermA, ermB, ermC and mefA, among them ermB gene coding constitutive MLSB phenotype is most frequent. Characteristics of the resistance indicate that multidrug resistant strains account a large proportion,and some correlations seem to exist between the resistance and the serotype.Erm and mef genes are all acquired drug-resistance genes, located in transposons or plasmids, which can disseminate generally between bacteria. It is very important to use antibacterial agent rationally, enhance resistance monitoring, develop new drug and vaccine to slow down the emerging and spreading of the drug-resistance.