Effect of dietary black rice outer layer fraction on inducible nitric oxide synthase expression in apoE-deficient mice |
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Authors: | XIA Min ZHU Hui-lian MA Jing ZHANG Yu-mei TANG Zhi-hong LING Wen-hua |
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Affiliation: | School of Public Health, Sun Yat-sen University, Guangzhou 510089, China |
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Abstract: | AIM: To explore the effect of dietary black rice outlayer fraction (BRF) on inducible nitric oxide synthase (iNOS) expression, and elucidate the possible mechanism of BRF anti-atherogenesis in apoE-deficient mice. METHODS: After 16 weeks intervention by 5% BRF, aortic iNOS activity in different groups was determined by RIA. iNOS mRNA expression in aorta were analyzed by RT-PCR. RESULTS: Mice in BRF group showed weaker expression of iNOS mRNA and lower iNOS activity than those in positive and WRF group (P<0.05). No significant difference was observed between positive group and WRF group (P>0.05). CONCLUSION:The supplementation of BRF has dra- matically reduced aortic sinus atherosclerotic plaque areas compared to WRF in apoE-deficient mice and its action of ant-atherogenesis may be attributed to its inhibition of iNOS activity and iNOS mRNA expression. |
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Keywords: | Apolipoproteins E Nitric oxide-synthase Arteriosclerosis Gene deletion |
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