Effect of streptomycin on electrophysiological changes caused by rising of left ventricular afterload in rabbits |
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Authors: | WANG Xing-xiang CHEN Jun-zhu CHENG Long-xian ZHU Jian-hua GUO Xiao-gang SHANG Yun-peng |
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Institution: | 1. Department of Cardiovascular Disease, First Hospital Affiliated to Medical College of Zhejiang University, HangZhou 310003, China;
2. Department of Cardiovascular Disease, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China |
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Abstract: | AIM: The aim of this study was to study the changes of rabbit heart electrophysiological properties caused by increasing left ventricular afterload, and to assess the effects of streptomycin or verapamil on these changes. METHODS: The rabbit heart preparation in situ was used, and the afterload of left ventricle was increased by clipping in part the root of ascending aorta. The changes of heart electrophysiological parameters including relative refractory period (RRP), effective refractory period (ERP), monophasic action potential duration (MAPD90) and ventricular fibrillation threshold(VFT) were observed before and after altering the afterload of left ventricle and were compared in the absence and presence of streptomycin or verapamil. RESULTS: The rising of left ventricular afterload led to shortening of RRP, ERP and MAPD90, and to descent of VFT (P<0.01). Streptomycin inhibited these changes of heart electrophysiological parameters caused by elevation of left ventricular afterload. In contrast, verapamil had no effects on the afterload-related changes of RRP, ERP and MAPD90 (P>0.05) except increasing of VFT (P<0.01). CONCLUSION: The electrophysilogical effect of streptomycin appears consistent with inhibition of stretch-activated ion channels, suggesting that the stretch-activated ion channels might be involved in the afterload-related changes of heart electrophysiological properties. |
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Keywords: | Streptomycin Verapamil Rabbits Ventricular function left Ion channels |
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