Ximaoornatins A–C,Polyoxygenated Diterpenoids from the Hainan Soft Coral Sinularia ornata |
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| Authors: | Li-Li Sun Xu-Wen Li Yue-Wei Guo |
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| Institution: | 1.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China;2.University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China;3.Drug Discovery Shandong Laboratory, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, China |
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| Abstract: | Three complex polyoxygenated diterpenoids possessing uncommon tetradecahydro-2,13:6,9-diepoxybenzo10]annulene scaffold, namely ximaoornatins A–C (1–3), one new eunicellin-type diterpene, litophynin K (4), and a related known compound, litophynol B (5) were isolated from the South China Sea soft coral Sinularia ornata. The structures and absolute configurations of 1–4 were established by extensive spectroscopic analysis, X-ray diffraction analysis, and/or modified Mosher’s method. A plausible biosynthetic relationship of 1 and its potential precursor 4 was proposed. In a bioassay, none of the isolated compounds showed obvious anti-inflammatory activity on LPS-induced TNF-α release in RAW264.7 macrophages and PTP1B inhibitory effects. |
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| Keywords: | soft coral Sinularia ornata polyoxygenated diterpenoid stereochemistry activity |
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