Unique Cyclized Thiolopyrrolones from the Marine-Derived Streptomyces sp. BTBU20218885 |
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| Authors: | Fuhang Song Jiansen Hu Xinwan Zhang Wei Xu Jinpeng Yang Shaoyong Li Xiuli Xu |
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| Institution: | 1.School of Light Industry, Beijing Technology and Business University, Beijing 100048, China;2.Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China;3.School of Ocean Sciences, China University of Geosciences, Beijing 100083, China; (X.Z.); (W.X.); (J.Y.);4.School of Pharmacy, Tianjin Medical University, Tianjin 300070, China; |
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| Abstract: | Two new cyclized thiolopyrrolone derivatives, namely, thiolopyrrolone A (1) and 2,2-dioxidothiolutin (2), together with the kn own compound, thiolutin (3) were identified from a marine-derived Streptomyces sp. BTBU20218885, which was isolated from a mud sample collected from the coastal region of Xiamen, China. Their chemical structures were determined using spectroscopic data, including HRESIMS, 1D and 2D NMR techniques. 1 possessed a unique unsymmetrical sulfur-containing thiolopyrrolone structure. All the compounds were tested for bioactivities against Staphylococcus aureus, Escherichia coli, Bacille Calmette–Guérin (BCG), Mycobacterium tuberculosis, and Candida albicans. 1 displayed antibacterial activities against BCG, M. tuberculosis, and S. aureus with minimum inhibitory concentration (MIC) values of 10, 10, and 100 μg/mL, respectively. Thiolutin (3) showed antibacterial activities against E. coli, BCG, M. tuberculosis, and S. aureus with MIC values of 6.25, 0.3125, 0.625, and 3.125 μg/mL, respectively. |
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| Keywords: | marine-derived Streptomyces thiolopyrrolone antibacterial M tuberculosis |
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