Antihypertensive effect of an aqueous extract of the calyx of Hibiscus sabdariffa |
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Authors: | Mojiminiyi F B O Dikko M Muhammad B Y Ojobor P D Ajagbonna O P Okolo R U Igbokwe U V Mojiminiyi U E Fagbemi M A Bello S O Anga T J |
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Institution: | Department of Physiology, Usman Danfodio University, Sokoto, Nigeria. mojiminiyi@yahoo.co.uk |
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Abstract: | The present study was designed to investigate the efficacy of an aqueous calyx extract of Hibiscus sabdariffa (HS) in two forms of experimental hypertension: salt-induced and L-NAME (N(omega)-L-arginine methyl ester)-induced and in normotensive controls. The blood pressure and heart rate fell dose-dependently in both the hypertensive and normotensive rats after intravenous injection of 1-125 mg/kg of HS, suggesting that HS possesses anti-hypertensive, hypotensive and negative chronotropic effects. The fall in mean arterial pressure was significantly pronounced in the hypertensive rats (salt-induced: 94.4+/-8.6 mm Hg; L-NAME-induced: 136.5+/-10.3 mm Hg) than in the normotensive controls (50.2+/-5.1 mm Hg; P<0.05). |
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Keywords: | Hibiscus sabdariffa Hypertension Antihypertensive effect |
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