Dantrolene may prevent organophosphate-induced oxidative stress and muscle injury |
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Authors: | Mehmet Emin Büyükokuro?lu Mustafa Cemek Yusuf Yürümez Yücel Yavuz |
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Institution: | a Department of Pharmacology, Faculty of Medicine, Afyon Kocatepe University, Ali Çetinkaya Kampüsü, ?zmir yolu 8. km, TR-03200 Afyonkarahisar, Turkey b Department of Chemistry (Biochemistry Division), Faculty of Sciences and Arts, Kocatepe University, Afyonkarahisar, Turkey c Department of Histology and Embryology, Faculty of Medicine, Kocatepe University, Afyonkarahisar, Turkey d Department of Emergency Medicine, Faculty of Medicine, Kocatepe University, Afyonkarahisar, Turkey e Department of Anatomy, Faculty of Medicine, Kocatepe University, Afyonkarahisar, Turkey |
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Abstract: | The effects of dantrolene against fenthion-induced oxidative stress and muscle injury were investigated in rats. Malondialdehyde (MDA), reduced glutathione (GSH) ascorbic acid, retinol and β-carotene levels in blood were measured. Histopathological alterations and apoptosis in diaphragm were examined. Fenthion increased the level of MDA and decreased the levels of GSH in blood. Dantrolene administration prevented the rise in MDA levels and increased the GSH levels. There was no significant difference between β-carotene levels of experimental groups. However, fenthion toxicity led to decrease in ascorbic acid and retinol levels, dantrolene administration significantly prevented this decrease. Dantrolene significantly decreased the inflammation, edema and muscle necrosis or apoptosis in diaphragm muscle. Results of present study showed that toxicity of organophosphate compound fenthion increases the lipid peroxidation and depresses endogenous antioxidative systems, and leads to muscle injury in organism. Again, dantrolene administration prevents lipid peroxidation, augments antioxidant activity, and decreases muscle injury and apoptosis. |
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Keywords: | Dantrolene Fenthion Muscle injury Organophosphate Oxidative stress |
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