芩连液与白虎汤对脂多糖致家兔肝损伤的疗效比较

为比较自拟方芩连液和白虎汤对高热病症的治疗效果,通过静脉注射脂多糖(LPS)复制了家兔高热病症,并在两种药物治疗前后分别进行了肝脏组织病理观察与血清生化指标分析。结果显示,15 μg/kg LPS能致家兔肝脏组织产生明显病理损伤,血清丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)和尿素(Urea)含量上升,而总胆固醇(TC)含量下降,经白虎汤和芩连液治疗后肝脏组织病理损伤显著减轻,4项血清生化指标向正常水平恢复。结果表明,白虎汤和芩连液对LPS引起的肝损伤都具有显著的治愈效果,且两种组方的疗效各有优势。

Compared Effect of Qinlian Liquid and Baihu Soup on Liver Lesion Induced by LPS in Rabbit

To compare the efficacy of Qinlian liquid with Baihu soup on ''fever disease symptom’, LPS was injected intravenously to form fever disease symptom in rabbit, and pathologic observation in liver tissue and serum biochemical analysis was conducted before and after treatment with the two kinds of formula respectively. The results showed that rabbit liver lesion was caused by 15 μg/kg LPS strikingly, and the levels of serum ALT, AST and Urea were increased, while TC was decreased. Then, after treatment with Qinlian liquid and Baihu soup, the liver lesion was cured and the concentration of four serum biochemical index returned to normal levels. The results indicated the liver lesion can be cured by Qinlian liquid and Baihu soup, and two formulas have their own advantages.