Bioactive constituents from the stems of Dalbergia parviflora |
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| Authors: | Uraiwan Songsiang Suchana Wanich Siripit Pitchuanchom Siwames Netsopa Komphet Uanporn Chavi Yenjai |
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| Institution: | aNatural Products Research Unit, Center of Excellence for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand |
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| Abstract: | From the stems of Dalbergia parviflora, three known flavonoids, six known isoflavonoids, a new isoflavone, dalparvone (2) and a new cinnamyl derivative, dalparvinene (6) were isolated and characterized. Isoflavan 3 exhibited strong cytotoxicity against KB and NCI-H187 cell lines with IC50 values of 0.53 and 2.04 μg/ml, respectively. Compound 6 demonstrated strong cytotoxicity against NCI-H187 with an IC50 value of 1.46 μg/ml. Compounds 4 and 6 possessed moderate cytotoxicity against KB cells with IC50 values of 6.78 and 9.89 μg/ml, respectively. In addition, 2 exhibited moderate antiplasmodial activity with an IC50 value of 8.19 μg/ml. |
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| Keywords: | Dalbergia parviflora Cytotoxicity Antimalarial Dalparvone Dalparvinene |
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