复合不育剂EP-1对小鼠空间记忆与焦虑行为的影响 |
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作者姓名: | 王晓佳 秦婷婷 胡霞 胡纤 黄银春 张洪茂 |
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基金项目: | 国家自然科学基金(31172102);华中师范大学科研项目(CCNU11A02010) |
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摘 要: | EP-1是由炔雌醚和左炔诺孕酮按照1:2的比例配制而成的一种用于鼠类不育控制的激素类复合不育剂,对鼠类的繁殖及繁殖行为等有一定影响,但对鼠类空间学习与记忆、焦虑行为等非繁殖行为的影响还没有报道。为此,用0 (对照)、1.0、2.0、3.0 mg/kg剂量的EP-1对昆明小鼠(Mus musculus)进行灌胃处理,然后用Morris水迷宫和高架十字迷宫分别测定其空间记忆、焦虑行为。结果发现灌胃后15 d,剂量为2.0 mg/kg的EP-1使小鼠空间记忆能力显著下降,但30 d后其空间记忆能力有所恢复,表明2.0 mg/kg剂量的EP-1可以在一定时间范围内降低小鼠的空间记忆能力。但不同剂量的EP-1对小鼠焦虑行为无显著影响。该结果可以为从对非繁殖行为的影响的角度研究EP-1对鼠类的作用提供一定启示。
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关 键 词: | 昆明小鼠(Mus musculus) EP-1 空间记忆 焦虑 |
收稿时间: | 2012/6/9 0:00:00 |
Effects of EP-1 on spatial memory and anxiety in Mus musculus |
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Authors: | WANG Xiaoji QIN Tingting HU Xi HU Qian HUANG Yinchun and ZHANG Hongmao |
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Abstract: | It has been reported that the EP-1, a contraceptive compound composed of levonorgestrel and quinestrol with the ratio of 1:2, has negative effects on the breeding and reproductive behaviors in some species of mice and rats. However, little is known that the effects of EP-1 on spatial memory and anxiety in mice. Here, the effects of treatment time (15 d and 30 d) and dose (0 mg/kg (control), 1.0 mg/kg, 2.0 mg/kg, 3.0 mg/kg) of EP-1 on spatial memory and anxiety in Mus musculus were tested using Morris water maze and elevated plus maze separately. Negative effects of 2.0 mg/kg EP-1 on spatial memory of the subjects were found in 15 days, and this ability recovered in 30 days, implying the 2.0 mg/kg EP-1 can decrease the ability of spatial memory of M. musculus within a period of time. No significant effects were found in all treatments of time and dose of EP-1 on anxiety of the subjects. The results might help to evaluate the effects of EP-1 on mice in respect to non-reproductive behaviors. |
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Keywords: | anxiety EP-1 Mus musculus spatial memory |
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