| 芎麻汤及其提取物对利血平低5-HT型偏头痛模型小鼠的影响 |
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| 作者姓名： | 刘顶鼎 郭建生 曾贵荣 张猛 郭倩瑶 侯春久 |
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| 作者单位： | 湖南中医药大学； |
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| 基金项目： | 湖南省教育厅科研基金资助项目(06C615);湖南省研究生科研创新项目(CX2010B351 |
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| 摘 要： | 目的探讨芎麻汤及其提取物对利血平所致低5-HT型偏头痛小鼠的作用机制,初步筛选芎麻汤的有效部位。方法采用皮下注射利血平(1 mg/kg)14 d复制偏头痛模型,观察芎麻汤及其提取物对利血平偏头痛小鼠体质量、凝血时间及血浆中5-HT、NO含量的影响。结果芎麻汤、芎麻汤正丁醇提取物组能增加偏头痛小鼠的体质量,调节5-HT的过度降低;芎麻汤、芎麻汤正丁醇提取物、芎麻汤乙酸乙酯提取物组能延长偏头痛小鼠的凝血时间,提高血浆中NO的含量,与模型组比较,差异具有统计学意义(P<0.01)。结论芎麻汤及其乙酸乙酯提取物、正丁醇提取物具有治疗利血平所致小鼠偏头痛的作用。
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| 关 键 词： | 芎麻汤及其提取物 偏头痛 小鼠 川芎 天麻 |
Effects of XiongMa decoction and its extracts
on migrane model of low 5-HT induced by reserpine |
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| Authors: | LIU Ding-ding GUO Jian-sheng ZENG Gui-rong ZHANG Meng GUO Qian-yao HOU Chun-jiu |
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| Institution: | LIU Ding-ding, GUO Jian-sheng, ZENG Gui-rong, ZHANG Meng, GUO Qian-yao,
HOU Chun-jiu |
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| Abstract: | To study the role of Xiongma decoction and its extracts on
the migrane model mouse of low 5 -HT by reserpine, and screen the effective parts of Xiong
Ma decoction preliminarily. MethodsThe migraine mouse model was reproduced by subcutaneous
injection reserpine in a dose of 1 mg/kg once every day and lasted for 14 days. The effects of
XiongMa decoction and its extracts on weight, coagulation time and 5 -HT and NO content were
observed. Results Compared with the modeling group, Xiongma decoction and its Butanol ex
tract could increase mouse weight and prevent excessive decrease of 5-HT; Xiongma decoction and
its Butanol extract and Ethyl acetate extract could prolong the coagulation time and improve
the content of NO ( <0.01). ConclusionXiongma decoction and its Ethyl acetate extract and Bu
tanol extract were effective on migraine mice induced by reserpine. |
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| Keywords: | Xiongma decoction and its extracts migraine mice Szechwan Lovage Rhizome Tall Gastrodia Tuber |
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