Benzpyrimoxan: Design,synthesis, and biological activity of a novel insecticide |
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Authors: | Eikoh Satoh Ryota Kasahara Kosuke Fukatsu Takao Aoki Hiroto Harayama Tetsuya Murata |
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Institution: | 1.Research Center, Research Division, Nihon Nohyaku Co., Ltd., 345 Oyamada-cho, Kawachi-nagano, Osaka 586–0094, Japan |
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Abstract: | Benzpyrimoxan (5-(1,3-dioxan-2-yl)-4-{4-(trifluoromethyl)phenyl]methoxy}pyrimidine, NNI-1501) was discovered as a novel insecticide structurally characterized by a pyrimidine derivative substituted with 1,3-dioxanyl and 4-trifluoromethylbenzyloxy groups. The compound showed remarkable activity against nymphs of rice planthoppers, including strains resistant to existing insecticides. Furthermore, benzpyrimoxan had low adverse effects on pollinators and beneficial arthropods. Because of these features, benzpyrimoxan is expected to be a suitable part of an integrated pest management strategy. In this report, the history of the discovery to reach benzpyrimoxan and details of the structure–activity relationships are described. |
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Keywords: | benzpyrimoxan NNI-1501 insecticide rice planthoppers insect growth regulator integrated pest management |
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