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| 阿魏酸钠对抗鼠肝缺血再灌注损伤的研究 | |
| 引用本文： | 贺德 曹绣虎. 阿魏酸钠对抗鼠肝缺血再灌注损伤的研究[J]. 湛江医学院学报, 1997, 15(1): 9-10,12 |
| 作者姓名： | 贺德 曹绣虎 |
| 作者单位： | [1]深圳市宝安区人民医院外科 [2]中山医科大学附属一院肝胆外科 |
| 摘 要： | 目的：观察阿魏酸钠（ＳＦ）对肝缺血再灌注损伤的保护作用。方法：将１６只成年雄性ＳＤ大鼠随机分为对照组和ＳＦ保护组，以大鼠肝门断流１ｈ再开放建立肝缺血再灌注损伤模型，在肝缺血前及肝再灌注２ｈ时测肝组织丙二醛（ＭＤＡ）、超氧化物歧化酶（ＳＯＤ）和测血ＡＫＰ、ＳＧＰＴ、ＳＧＯＴ并取肝组织作光镜及电镜检查。结果：对照组再灌注２ｈ时ＭＤＡ、ＳＧＰＴ、ＳＧＯＴ，的升高及ＳＯＤ活力下降均较ＳＦ保护组明显（Ｐ〈０ |
| 关 键 词： | 阿魏酸钠 肝缺血 再灌注损伤 肝脏保护 |
THE PREVENTIVE EFFECT OF SODIUM FERULATE ON THE DAMAGE OF ISCHEMIA-REPERFUSION IN RAT LIVER |
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| He De, Cao Xiuhu. THE PREVENTIVE EFFECT OF SODIUM FERULATE ON THE DAMAGE OF ISCHEMIA-REPERFUSION IN RAT LIVER[J]. Journal of Guangdong Medical College, 1997, 15(1): 9-10,12 | |
| Authors: | He De Cao Xiuhu |
| Abstract: | Objective: To observe the preventive effect of Sodium Ferulate (SF)on thc damage of ischemia-reperfusion in rat liver. Methods: 16 rats were put randomly into SF protection group and control group.The animal model of hepatic ischemia was made by temporarily blocking the blood stream in porta hepatis for one hour. The malondialdehyde (MDA),superoxide dismistase (SOD)in liver tissue and alkaline phosphatase (AKP),SGPT,SGOT in serum were measurcd before hepatic ischemia and after two hours of ischemia, respectivcly,and the severity of the hepatic tissue damage was examined under light and electronic mlcroscope. Results: Increasing of MDA,SGPT,SGOT and decreasing of SOD were more obvious in group as compared with the SF protection group (P<0. 01). Conclusion: SF has significantly protective effect on the damage of ischemia-reperfusion in rat liver. |
| Keywords: | superoxide dismistase sodium ferulate liver ischemia damage of reperfusion |
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