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Humoral immune response to immediate-early protein of pseudorabies virus in swine with induced or naturally acquired infection
Authors:A K Cheung
Institution:National Animal Disease Center, USDA, Ames, LA 50010.
Abstract:Pseudorabies virus (PRV) immediate-early (IE) protein is a nonglycosylated polypeptide localized in the nuclei of infected cells. The IE protein is a regulatory protein that is only synthesized during viral replication and is presented to the immune system of PRV-infected swine. Antibodies to the IE protein were demonstrated in swine with induced or naturally acquired infection. However, antiserum raised against purified IE protein could not neutralize PRV in vitro.
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