Comparative effects of DDT,allethrin, dieldrin and aldrin-transdiol on sense organs of Xenopus laevis |
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Authors: | LMA Akkermans J van den Bercken M Versluijs-Helder |
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Institution: | Institute of Veterinary Pharmacology and Toxicology, University of Utrecht, Utrecht, The Netherlands |
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Abstract: | The effects of DDT, allethrin, dieldrin and aldrin-transdiol were studied in two different sense organs of Xenopus laevis; the lateral-line organ and the cutaneous touch receptors. DDT and allethrin produced pronounced repetitive firing in both preparations. Dieldrin and aldrin-transdiol, on the other hand, failed to induce any sign of repetitive activity. Aldrin-transdiol, however, caused a marked increase in the rate of spontaneous firing of the lateral-line organ, later followed by a blockade. The repetitive activity in the cutaneous touch receptors, whether induced by DDT or allethrin, was not distinguishable from repetitive firing of the afferent nerve fibers and showed no marked dependence on temperature. This contrasts sharply with the know negative temperature coefficient of the DDT- or allethrin-induced repetitive activity in the lateral-line organ. |
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