Conversion of the aldrin/dieldrin metabolite dihydrochlordene dicarboxylic acid-14C in rats |
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| Authors: | J.P. Lay I. Weisgerber W. Klein |
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| Affiliation: | Institut für ökologische Chemie der Gesellschaft für Strahlen- und Umweltforschung mbH, München. D-5205 St. Augustin 1, Schloß Birlinghoven, Germany |
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| Abstract: | Upon intravenous application of dihydrochlordene dicarboxylic acid-14C to rats, the radioactivity is quickly excreted, and 44% of the excreted radioactivity consists of metabolites. Nine metabolites have been isolated from feces and urine extracts. Three metabolites could be identified by means of authentic samples by thin layer chromatography, gas chromatography, and mass spectrometry: two isomers of dechlorodihydrochlordene-dicarboxylic acid (metabolites I and II, total 22.5%) and dihydrochlordene-dicarboxylic acid-dimethyl-ester (metabolite III, 11.3%). |
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