Dogs mean arterial pressure and heart rate responses during high propofol plasma concentrations estimated by a pharmacokinetic model |
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| Authors: | Silva Aura Ribeiro Lénio M Bressan Nadja Oliveira Pedro Ferreira David A Antunes Luís M |
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| Institution: | aDepartamento de Ciências Veterinárias, Universidade de Trás-os-Montes e Alto Douro, Vila Real, Portugal;bHospital Veterinário do Porto, Portugal;cFaculdade de Engenharia da Universidade do Porto, Portugal;dInstituto de Biologia Molecular e Celular, Porto, Portugal;eInstituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto, Porto, Portugal;fCECAV, Universidade de Trás-os-Montes e Alto Douro, Vila Real, Portugal |
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| Abstract: | Propofol total intravenous anesthesia should provide stability of the cardiovascular system. In this study, mean arterial pressure and heart rate were evaluated in eight healthy dogs anesthetized with increasing rates of propofol. The cerebral state index (CSI) was studied as an additional parameter. Although the estimated propofol plasma concentration reached a maximal value of 15.3 μg ml−1, no hypotension or bradycardia were observed. Exploration of each animal’s data revealed high inter-individual variability regarding mean arterial pressure and heart rate. Considering the logarithmic of the concentration, a moderate depressant effect of propofol on mean arterial pressure was revealed in five dogs but the effect was not followed on heart rate. |
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| Keywords: | Anesthesia Propofol Haemodynamics Total intravenous anesthesia Cerebral state index |
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