Progress in expression and function of tricellular tight junction protein tricellulin |
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Authors: | MAO Xiang-di YANG Ze-xi CONG Xin |
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Institution: | 1.Department of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences;2.School of Clinical Medicine, Peking University Health Science Center, Beijing 100191, China |
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Abstract: | Tricellulin is a novel tight junction protein that is specially expressed in tricellular contacts. Tricellulin is expressed in multiple epithelial and endothelial cells and plays an important role in regulating the paracellular transport of substances and maintaining the integrity of tight junction complexes. The abnormal expression and dysfunction of tricellulin are closely related to the occurrence and development of deafness, inflammatory bowel disease, bacterial infection diseases, tumors and damage to the blood-brain barrier and the blood-retinal barrier. In this review, the research progress on the molecular structure, expression and distribution of tricellulin, the relationship between tricellulin function and diseases as well as the relevant regulatory mechanisms are presented. |
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Keywords: | Tricellulin Tight junction Paracellular pathway Epithelial cells Endothelial cells |
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