GPR54及Kisspeptins在动物青春期启动中的作用

G蛋白偶联受体GPR54是新发现的视黄酸家族成员之一,Kisspeptins是其内源性配体,两者均是动物体内的肽类物质,其在不同动物体内的分布区域有差异,但均与青春期启动密切相关。试验证明猪GPR54基因与下丘脑、垂体、卵巢发育性表达有关,GPR54系统在斜带石斑鱼性逆转过程中发挥作用,大鼠GPR54突变者性发育低下等。GPR54/Kisspeptins在调节动物体内促性腺激素LH和FSH的释放、促进生殖器官的发育及青春期启动中均具有重要的作用。

Function of GPR54 and Kisspeptins in Onset of Animal Puberty

GPR54(G-protein-coupled receptor 54)is one of new discovered RAR family,Kisspeptins is its endogenous ligand.They both are peptides in animals,and distribute into different areas,but both of them play important roles in the onset of puberty.Experiments indicated that genes of swines′ GPR54 have connection with development of hypogonadism,pituitary,ovary.GPR54/Kisspeptins play important roles in the course of the sex reverses for Epinephelus coioides.Sexual development of GPR54 mutations is low.Animal experiments indicated that GPR54/Kisspeptins play important roles in adjusting the release of gonadotropin LH and FSH,and promoting development of genitals and in the onset of puberty.