| 阿克替苷抑制大鼠前列腺增生的药理学研究 |
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| 引用本文： | 孙卫东,陈飞,孙云. 阿克替苷抑制大鼠前列腺增生的药理学研究[J]. 扬州大学学报(农业与生命科学版), 2008, 29(4) |
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| 作者姓名： | 孙卫东 陈飞 孙云 |
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| 作者单位： | 扬州市中医院,江苏,扬州,225009;扬州大学,医学院,江苏,扬州,225001 |
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| 基金项目： | 江苏省中医药局资助项目(K0110276) |
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| 摘 要： | 建立良性前列腺增生大鼠模型,用不同剂量的阿克替苷灌胃4周,研究肉苁蓉的化学成分阿克替苷对前列腺增生大鼠前列腺细胞凋亡和超微结构的影响。结果表明：模型组细胞凋亡率较低;高剂量阿克替苷处理后,大鼠前列腺细胞凋亡率明显高于模型组。超微结构显示阿克替苷较模型组细胞核完整,细胞核浓缩不明显,细胞核致密度增高,粗面内质网空泡减少。证明阿克替苷能促进细胞凋亡,对超微结构有明显的改善作用,因而抑制前列腺增生。
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| 关 键 词： | 阿克替苷 大鼠 前列腺增生 细胞凋亡 超微结构 |
The pharmacological research of acteoside on the action inhibited begnin prostatic hyperplasia in rats |
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| SUN Wei-dong,CHEN Fei,SUN Yun. The pharmacological research of acteoside on the action inhibited begnin prostatic hyperplasia in rats[J]. Journal of Yangzhou University(Agricultural and Life Science Edition), 2008, 29(4) |
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| Authors: | SUN Wei-dong CHEN Fei SUN Yun |
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| Affiliation: | 1.Yangzhou Hosp of Trad Chinese Med;Yangzhou 225009;China;2.Coll of Med;Yangzhou Univ;Yangzhou 225001;China |
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| Abstract: | The begnin prostatic hyperplasia(BPH) rat model was established,and three dose groups of acteoside were orally administrated for 4 weeks,to study the effect of acteoside distilled from Cistanche tubulosa on apoptosis and ultramicrostructure prostate gland in rats with BPH.The ultrastructural change of the prostate gland was observed by the transmission electron microscopy.Results showed that Apoptosis of normal rat prostate was not obvious,there wase low rate of prostate apoptosis in the model group,in the ... |
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| Keywords: | acteoside rat begnin prostatic hyperplasia apoptosis ultrastructural |
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