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盐酸林可霉素-硫酸大观霉素混悬注射液在猪体内的药动学研究
引用本文:范惠敏,王忠,王立琦,叶严锋,黄显会,曾振灵. 盐酸林可霉素-硫酸大观霉素混悬注射液在猪体内的药动学研究[J]. 华南农业大学学报, 2012, 33(2): 244-247
作者姓名:范惠敏  王忠  王立琦  叶严锋  黄显会  曾振灵
作者单位:华南农业大学兽医学院,广东省兽药研制与安全评价重点实验室,广东广州510642
基金项目:“十一五”国家科技支撑计划重点项目(2006BAD31B06)
摘    要:8头健康猪按体质量单次深部肌内注射盐酸林可霉素-硫酸大观霉素(5 mg.kg-1林可霉素,10 mg·kg-1大观霉素)混悬注射液后,用高效液相色谱法分别测定林可霉素和大观霉素的血药浓度,使用非房室统计矩分析方法处理得到血药浓度-时间数据.林可霉素主要药动学参数分别为:ke=(0.21±0.01)h-1;t1/2β=(3.38±0.09)h;tmax=(0.29±0.02)h;Cmax=(5.15±0.18)μg·mL-1;AUC0~LOQ=(10.27±0.38)μg·mL-1.h;MRT=(3.52±0.11)h;ClB/F=(0.46±0.01)L·h-1·kg-1;VZ/F=(2.26±0.12)L·kg-1.大观霉素主要药动学参数分别为:ke=(0.43±0.01)h-1;t1/2β=(1.64±0.06)h;tmax=(0.44±0.03)h;Cmax=(20.05±0.70)μg·mL-1;AUC0~LOQ=(51.82±0.98)μg·mL-1·h;MRT=(2.39±0.04)h;ClB/F=(0.19±0.01)L·h-1·kg-1;VZ/F=(0.46±0.02)L·kg-1.结果表明,肌内注射盐酸林可霉素-硫酸大观霉素混悬注射液后,两药均迅速吸收并快速消除,但后者吸收稍慢,消除较快.

关 键 词:盐酸林可霉素-硫酸大观霉素  混悬注射液  药动学  
收稿时间:2011-04-01

Pharmacokinetics of Lincomycin Hydrochloride and Spectinomycin Sulfate Suspension for Injection in Swine
FAN Hui-min,WANG Zhong,WANG Li-qi,YE Yan-feng,HUANG Xian-hui and ZENG Zhen-ling. Pharmacokinetics of Lincomycin Hydrochloride and Spectinomycin Sulfate Suspension for Injection in Swine[J]. JOURNAL OF SOUTH CHINA AGRICULTURAL UNIVERSITY, 2012, 33(2): 244-247
Authors:FAN Hui-min  WANG Zhong  WANG Li-qi  YE Yan-feng  HUANG Xian-hui  ZENG Zhen-ling
Affiliation:(Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine,South China Agricultural University,Guangzhou 510642,China)
Abstract:The lincomycin hydrochloride and spectinomycin sulfate suspension was injected into the neck muscle in 8 healthy pigs(5 mg·kg-1 lincomycin,10 mg·kg-1spectinomycin).The concentrations of lincomycin and spectinomycin in plasma were determined by HPLC with UV detection,respectively.The plasma concentration-time data were fit to a non-compartmental analysis based on statistical moment theory.The main pharmacokinetic parameters of lincomycin were as follows: ke=(0.21±0.01) h-1;t1/2β=(3.38±0.09) h;tmax=(0.29±0.02) h;Cmax=(5.15±0.18) μg·mL-1;AUC0~LOQ=(10.27±0.38) μg·mL-1·h;MRT=(3.52±0.11) h;ClB/F =(0.46±0.01) L·h-1·kg-1;VZ/F =(2.26±0.12) L·kg-1,whereas,those of spectinomycin were: ke=(0.43±0.01) h-1;t1/2β=(1.64±0.06) h;tmax=(0.44±0.03) h;Cmax=(20.05±0.70) μg·mL-1;AUC0~LOQ=(51.82±0.98) μg·mL-1·h;MRT=(2.39±0.04) h;ClB/F =(0.19±0.01) L·h-1·kg-1;VZ/F =(0.46±0.02) L·kg-1.It was noted that both lincomycin hydrochloride and spectinomycin sulfate were rapidly absorbed and eliminated,however,the latter was more slowly absorbed but more rapidly eliminated after the intramuscular administration of lincomycin hydrochloride and spectinomycin sulfate suspension in pigs.
Keywords:lincomycin hydrochloride and spectinomycin sulfate  suspension for injection  pharmacokinetics  swine
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