不同周龄大耳白兔血液生理生化指标的测定

为了明确大耳白兔中国兽药监察所封闭群的生物学特性，对其血液生理生化指标进行了测定。选5、10及13周龄的雄兔和雌兔。空腹采血测定红细胞、白细胞等16项血液生理指标和血糖、总蛋白等16项生化指标。10周龄的红细胞数、白细胞数、红细胞压积和平均红细胞血红蛋白含量高于5周龄和13周龄，雌雄间血液生理指标无明显差异，血清丙氨酸转氨酶含量随着周龄的增加而升高，碱性磷酸则随着周龄的增加而下降。与日本大耳白兔相比，主要血液生理指标比较接近，丙氨酸转氨酸、白蛋白、尿素氮、直接胆红素等血液生化指标相近，其他指标有所不同。测定结果表明，该封闭群具有不同于日本大耳白兔（Slc:JW/CSK)的生物学特性。

Age-Related Changes in Hematological and Serum Biochemical Values of White Rabbits

The colony of white rabbits from National Institute for Control of Veterinary Bioproducts and Pharmaceuticals (NICVBP) is a new colony. In this paper, hematological and serum biochemical values in white rabbits were determined. Using male and female rabbits in 5, 10 and 13 weeks old, collected blood after 12h fast, 16 values in the hematology (RBC, WBC, PLT, HGB, etc.) and 16 values in biochemistry (ALT, AST, ALP, GLU,CHO, BUN, CRE, etc.) were determined. RBC, WBC, HCT and MCHC values in 10 week old were higher than 5 and 13 weeks old, there were no significant differences between male and female; ALT value was increased by age, but ALP value was decreased by age. Compared with Sla:JW/CSK rabbits, main hematological values and ALT, ALB, BUN and T.BIL values were approximate, but other values were different. These findings suggest that the NICVBP:JW rabbits has different characteristics with Slc:JW/CSK rabbtis.