| Abstract: | The histoincompatibility determined by one or more genes on the X chromosome of the mouse effects a complete rejection of skin of the (C57BL/6 female symbol x BALB/c male symbol) F(1) hybrid male grafted onto the reciprocal type F(1) hybrid male, but only an incomplete rejection of either reciprocal type F(1) hybrid female skin, grafted onto the same type of male host. The resulting mosaic survival pattern of the female graft is interpreted as support for the Lyon hypothesis of X-chromosome inactivation. |
