Association of polymorphisms in sire KCNQ3 potassium voltage-gated channel gene with cow milk-fat content

Association of the effects of the SNPs in the KCNQ3 and KCNB2 genes with breeding value of bulls of the holsteinized Black-and-White breed has been verified. The reliable influence of SNP (rs41610985) in the KCNB2 gene on the breeding value of bulls is not revealed. The SNP marker (rs41580517) in the KCNQ3 gene is associated with fat content in milk. In addition, the effect of a G to C allele substitution is equal to 0.044, and domination of allele G is observed. It was ascertained that the causal mutation should be located in the KCNQ3 gene, and, consequently, this gene is a candidate gene stipulating the SNP marker (rs41580517) association with the fat content in milk.