Disposition of flunixin meglumine injectable preparation administered orally to healthy horses |
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Authors: | Pellegrini-Masini A Poppenga R H Sweeney R W |
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Affiliation: | Department of Clinical Studies-New Bolton Center, and Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, 382 West Street Road, Kennett Square, PA 19348, USA. amasini@vet.upenn.edu |
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Abstract: | An injectable preparation of flunixin meglumine was administered orally and intravenously at a dose of 1.1 mg/kg to six healthy adult horses in a cross-over design. Flunixin meglumine was detected in plasma within 15 min of administration and peak plasma concentrations were observed 45-60 min after oral administration. Mean bioavailability of the oral drug was 71.9 +/- 26.0%, with an absorption half-life of 0.76 h. The apparent elimination half-life after oral administration was 2.4 h. The injectable preparation of flunixin meglumine is suitable for oral administration to horses. |
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