异香豆素噁二唑类化合物的合成及除草活性

为了寻找具有较高除草活性的异香豆素类化合物，设计合成了16个新型异香豆素噁二唑类化合物4a～4p，其结构均经核磁共振氢谱、碳谱及高分辨质谱确证。初步除草活性测定结果表明，部分目标化合物在500 mg/L下对马唐Digitaria sanguinalis L.和反枝苋Amaranthusretroflexus L.具有一定的除草活性，其中化合物4j（4-5-（4-氯-苯基）-1，2，4]二唑-3-基]-3-己基-6，7-二甲氧基异香豆素）的活性最好，对马唐和反枝苋的致死率分别为64%和62%。

Synthesis and herbicidal activity of several substituted isocoumarin oxadiazole

In order to get a series of isocoumarin compounds with high herbicidal activity, 16 substituted oxadiazole 4a-4p were synthesized. All the target compounds were characterized by ¹H NMR, ¹³C NMR and HRMS. Preliminary screening with Digitaria sanguinalis L. and Amaranthus retroflexus L. demonstrated that some of the target compounds exhibited herbicidal activity at the concentrations of 500 mg/L. 4j, 4-(5-(4-chlorophenyl)-1, 2, 4-oxadiazol-3-yl)-3-hexyl-6, 7-dimethoxy-1H-isochromen-1-one had the best effect to D. sanguinalis and A. retroflexus of which the mortality rates were 64% and 62%.