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Effect of Rous associated virus number 7 on lymphoid cells and tissues of the chicken
Authors:J E Heidrich  M A Adcock  C Bolin  N F Cheville  R E Smith
Affiliation:1. Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523 USA;2. Pathological Laboratory, National Animal Disease Center, Ames, Iowa 50010USA;1. Department of Bioengineering, Imperial College London, London SW7 2AZ, UK;2. Centre for Synthetic Biology, Imperial College London, London SW7 2AZ, UK;3. Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK;4. SynbiCITE Innovation and Knowledge Centre, Imperial College London, London SW7 2AZ, UK;5. Discovery Biology, Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D, 431 50 Mölndal, Sweden;6. Hit Discovery, Discovery Sciences, IMED Biotech Unit, AstraZeneca, Macclesfield SK10 4TG, UK;1. School of Mechanical, Materials, Mechatronic and Biomedical Engineering, University of Wollongong, NSW 2522, Australia;2. School of Materials Science and Engineering, University of Science and Technology Liaoning, Liaoning 114051, PR China;1. Department of Agricultural and Applied Economics, University of Wisconsin–Madison, United States;2. Department of Statistics, University of Wisconsin–Madison, United States;1. Department of Medical Sciences, College of Medical and Health Sciences, Ambo University, Ethiopia;2. Department of Biomedical Sciences (Anatomy), College of Medical Sciences, Institute of Health, Jimma University, Ethiopia;3. Department of Pediatrics and Child Health, College of Medical Sciences, Institute of Health, Jimma University, Ethiopia
Abstract:Infection of chicks or chick embryos with Rous associated virus number 7 (RAV-7) led to a decreased blastogenic response to Concanavalin A (Con A) by lymphocytes isolated from the spleen and thymus. Chicks infected with RAV-7 8 days after hatch manifested decreased Con A blastogenesis 5 weeks postinfection, while chicks infected in ovo at 10 days of incubation showed an unusual pattern of cell density dependent decreased blastogenesis two weeks post-hatch (three weeks post-infection). Histopathological examination of tissues from RAV-7 infected chicks revealed evidence of lymphoid organ involution and widespread lymphoproliferative lesions by 3 weeks of age. The combination of decreased in vitro lymphoid blastogenesis and in vivo lymphoproliferation suggests that RAV-7 interacts with lymphocytes in a fashion that has not previously been described in the chicken.
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