| 重组禽α疱疹病毒研究进展 |
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| 引用本文： | 张馨月,张存,冉多良.重组禽α疱疹病毒研究进展[J].动物医学进展,2007,28(6):61-65. |
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| 作者姓名： | 张馨月 张存 冉多良 |
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| 作者单位： | 浙江省农科院畜牧兽医研究所,浙江杭州,310021;新疆农业大学动物医学学院,新疆乌鲁木齐,830052;浙江省农科院畜牧兽医研究所,浙江杭州,310021;新疆农业大学动物医学学院,新疆乌鲁木齐,830052 |
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| 摘 要： | 禽α疱疹病毒可以引起多种家禽重要传染病,重组病毒是研究其基因组结构功能和新型基因工程疫苗的有效手段.文章综述了禽α疱疹病毒转移载体的构建和同源重组方法、感染性细菌人工染色体系统、基因缺失疫苗和重组活载体疫苗的最新进展.
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| 关 键 词： | 禽α疱疹病毒 病毒载体 重组疫苗 |
| 文章编号： | 1007-5038（2007）06-0061-05 |
| 修稿时间： | 2007-04-09 |
Advance in Recombinant Avian alphaherpesvirus |
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| ZHANG Xin-yue,ZHANG Cun,RAN Duo-liang.Advance in Recombinant Avian alphaherpesvirus[J].Progress In Veterinary Medicine,2007,28(6):61-65. |
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| Authors: | ZHANG Xin-yue ZHANG Cun RAN Duo-liang |
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| Institution: | 1. Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences, Hangzhou, Zhejiang , 310021, China ; 2. College of Veterinary Science, Xinjiang Agricultural University, Urrnuqi , Xinjiang , 830052, China |
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| Abstract: | Avian alphaherpesviruses caused several infectious diseases that made large losses in domestic birds. The mutageneses of these viruses were reconstructed to identify their gene functions and to develop genetic engineering vaccines. This review summarized recent advances in the methods of construction of viral transfer plasmid, homologous recombinant, infectious bacterial artificial chromosome, and the activated vaccines derived from the viruses deleted the non-essential gene or inserted with neutralizing gene of other pathogens. |
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| Keywords: | Avian alphaherpervirus viral vector recombinant vaccine |
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