A reagin-like antibody in horse serum II. Anti-human IgE induced reversed cutaneous anaphylaxis-like responses in horse skin |
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| Authors: | Dr. A. G. Matthews P. Imlah E. A. McPherson |
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| Affiliation: | (1) Department of Veterinary Medicine, University of Edinburgh, Veterinary Field Station, Easter Bush, EH25 9RG Roslin, Midlothian, UK;(2) Department of Animal Health, University of Edinburgh, Veterinary Field Station, Easter Bush, EH25 9RG Roslin, Midlothian, UK;(3) Present address: Ratley Lodge, Ratley, Banbury, Oxford, UK |
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| Abstract: | Fc specific anti-human IgE serum induced prolonged reversed cutaneous anaphylaxis (RCA)-like reactions in horse skin. Morphologically and histologically, these reactions resembled passively induced late cutaneous anaphylaxis responses in human skin, but differed from reversed passive Arthus responses induced in horse skin using anti-horse IgG serum. The induction of RCA-like responses in horse skin by anti-human IgE indicates shared Fc antigenic determinants on human IgE and a horse homocytotropic or reagin-like antibody. |
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