Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase |
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| Authors: | Munn David H Sharma Madhav D Lee Jeffrey R Jhaver Kanchan G Johnson Theodore S Keskin Derin B Marshall Brendan Chandler Phillip Antonia Scott J Burgess Russell Slingluff Craig L Mellor Andrew L |
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| Institution: | Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA. dmunn@mail.mcg.edu |
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| Abstract: | Antigen-presenting cells (APCs) can induce tolerance or immunity. We describe a subset of human APCs that express indoleamine 2,3-dioxygenase (IDO) and inhibit T cell proliferation in vitro. IDO-positive APCs constituted a discrete subset identified by coexpression of the cell-surface markers CD123 and CCR6. In the dendritic cell (DC) lineage, IDO-mediated suppressor activity was present in fully mature as well as immature CD123+ DCs. IDO+ DCs could also be readily detected in vivo, which suggests that these cells may represent a regulatory subset of APCs in humans. |
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