重金属调控非选择性阳离子通道生理功能的研究进展

非选择性阳离子通道(NSCCs)是生物膜上能同时允许不通价态的阳离子通过的多种通道蛋白的集合体,参与了细胞的营养吸收、膨压控制、信号传导等许多生理过程。NSCCs能够快速转运Ca~(2+)、K~+、Mg~(2+)等细胞代谢必需的营养元素,也能转运有毒重金属离子。了解重金属离子与NSCCs的互作关系,对于调控植物对污染环境中有害重金属的吸收和转运过程具有重要意义。本文综述了重金属离子类型和浓度影响NSCCs门控机制的研究进展,为探索新型离子通道调控剂及其调控机理提供参考。

Advance in Regulation of Heavy Metals on Nonselective Cation Channels:A Review

Nonselective cation channels(NSCCs)are a diverse group of ion channels located on the biomembranes. They are directly involved in a lot of physiological processes as uptake of nutrients, turgor maintenance, signal conduction, etc. NSCCs are permeable to many essential cations like Ca2+, K+, Mg2+and toxic heavy metal cations as well. Understanding the interaction between heavy metal ions and NSCCs is of great importance in regulating the uptake of toxic heavy metal ions in plants when they are grown in contaminated environment. In this review, influence of ion types and concentrations on the gating mechanism of NSCCs were summarized. These advances would provide important ref-erences for developing new channel modulators and exploring the regulation mechanism of modulators on NSCCs.