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Antifungal activity evaluation of the constituents of Haliclona baeri and Haliclona cymaeformis, collected from the Gulf of Thailand
Authors:Wattanadilok Rawiwan  Sawangwong Pichan  Rodrigues Cátia  Cidade Honorina  Pinto Madalena  Pinto Eugenia  Silva Artur  Kijjoa Anake
Affiliation:Rawiwan Wattanadilok, Pichan Sawangwong, Cátia Rodrigues, Honorina Cidade, Madalena Pinto, Eugenia Pinto, Artur Silva, and Anake Kijjoa
Abstract:A new compound maleimide-5-oxime was isolated, together with 3,4-dihydroxybenzoic acid, tetillapyrone, from the ethyl acetate extract of the marine sponge Haliclona baeri while tetillapyrone, nortetillapyrone, p-hydroxybenzaldehyde and phenylacetic acid were isolated from the ethyl acetate extract of Haliclona cymaeformis, collected from the Gulf of Thailand. The structures of tetillapyrone and nortetillapyrone were re-examined using HMBC correlations. Maleimide-5-oxime, tetillapyrone and nortetillapyrone were found to be inactive against three human tumor cell lines (the estrogen-dependent ER(+) MCF-7, the estrogen-independent ER(−) MDA-MB-231 and NCI-H460. Maleimide-5-oxime, p-hydroxybenzaldehyde, phenylacetic acid, tetillapyrone and nortetillapyrone were evaluated for their growth inhibitory effect against seven yeasts and eight filamentous fungi. Only nortetillapyrone showed antifungal activity, with a preponderance on the dermatophytic filamentous fungi.
Keywords:Haliclona baeri   Haliclona cymaeformis   tetillapyrone   nortetillapyrone   antifungal activity   dermatophytes
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