基因编辑技术在贝类中的应用进展与展望

基因编辑是进行生物体遗传修饰的重要手段,已广泛应用于功能基因组学研究、动物模型制备、动植物遗传改良、基因治疗等多个研究领域.近年来CRISPR/Cas9技术的出现更是为生命科学领域带来一场技术革命,高效、精准、低成本的CRISPR技术已成为目前人们探究基因功能、解析生命现象的重要工具,在贝类中的应用也日益增多.本文就基...

Application advances and prospects of genome editing in molluscs

Genome editing is an important means of genetic modification of organisms. It has been widely used in a broad spectrum of fields, such as functional genomics, animal model generation, genetic improvement of animals and plants, and gene therapy. In recent years, the emergence of CRISPR/Cas9 technology has sparked a revolution in biological research. Efficient, accurate and low-cost CRISPR technology has become a useful tool to explore gene functions and elucidate life phenomena, and its application in molluscs is emerging rapidly. In this review, we introduced the developmental course and working mechanisms of gene editing technology, and its application and prospects in molluscs, which might promote further application of genome editing in more molluscan researches, and provide information for identification of gene functions, determining genes related to economic trait, genetic improvement.