Targeting malaria virulence and remodeling proteins to the host erythrocyte |
| |
Authors: | Marti Matthias Good Robert T Rug Melanie Knuepfer Ellen Cowman Alan F |
| |
Affiliation: | Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia. |
| |
Abstract: | To establish infection in the host, malaria parasites export remodeling and virulence proteins into the erythrocyte. These proteins can traverse a series of membranes, including the parasite membrane, the parasitophorous vacuole membrane, and the erythrocyte membrane. We show that a conserved pentameric sequence plays a central role in protein export into the host cell and predict the exported proteome in Plasmodium falciparum. We identified 400 putative erythrocyte-targeted proteins corresponding to approximately 8% of all predicted genes, with 225 virulence proteins and a further 160 proteins likely to be involved in remodeling of the host erythrocyte. The conservation of this signal across Plasmodium species has implications for the development of new antimalarials. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|