Clinical pharmacokinetics of norfloxacin-glycine acetate after intravenous and oral administration in pigs |
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Authors: | Zhi-Qiang Chang Byung-Chol Oh Jong-Choon Kim Kyu-Shik Jeong Myung-Heon Lee Hyo-In Yun Mi-Hyun Hwang Seung-Chun Park |
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Institution: | 1College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea.;2Lee Gil Ya Cancer and Diabetes Institute, Gachon University of Medicine and Science, Incheon 406-840, Korea.;3College of Veterinary Medicine, Chonnam National University, Kwangju 500-757, Korea.;4National Veterinary Research and Quarantine Service, Anyang 430-824, Korea.;5College of Veterinary Medicine, Chungnam National University, Daejeon 302-305, Korea. |
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Abstract: | The pharmacokinetics and dosage regimen of norfloxacin-glycine acetate (NFLXGA) was investigated in pigs after a single intravenous (i.v.) or oral (p.o.) administration at a dosage of 7.2 mg/kg body weight. After both i.v. and p.o. administration, plasma drug concentrations were best fitted to an open two-compartment model with a rapid distribution phase. After i.v. administration of NFLXGA, the distribution (t1/2α) and elimination half-life (t1/2β) were 0.36 ± 0.07 h and 7.42 ± 3.55 h, respectively. The volume of distribution of NFLXGA at steady state (Vdss) was 4.66 ± 1.39 l/kg. After p.o. administration of NFLXGA, the maximal absorption concentration (Cmax) was 0.43 ± 0.06 µg/ml at 1.36 ± 0.39 h (Tmax). The mean absorption (t1/2ka) and elimination half-life (t1/2β) of NFLXGA were 0.78 ± 0.27 h and 7.13 ± 1.41 h, respectively. The mean systemic bioavailability (F) after p.o. administration was 31.10 ± 15.16%. We suggest that the optimal dosage calculated from the pharmacokinetic parameters is 5.01 mg/kg per day i.v. or 16.12 mg/kg per day p.o. |
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Keywords: | norfloxacin pharmacokinetics pig |
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