银杏叶提取物对体外培养心肌膜微血管内皮细胞分泌NO和ET-1的影响 |
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作者姓名: | 田启超 张涛 胡格 田丽芳 穆祥 刘长松 |
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作者单位: | 四川农业大学动物科技学院,中国农业大学动物医学院,北京农学院北京市兽医学(中医药)重点实验室,北京农学院北京市兽医学(中医药)重点实验室,北京农学院北京市兽医学(中医药)重点实验室,四川农业大学动物科技学院 雅安625014 河北沧州职业技术学院 沧州061001,北京100094,北京102206,北京102206,北京102206,雅安625014 |
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基金项目: | 北京市自然科学基金;北京市教委学术创新团队 |
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摘 要: | 研究银杏叶提取物(EGb761)对微血管内皮细胞分泌NO和ET-1的影响。采用体外培养大鼠心肌膜微血管内皮细胞(RMMMVECs)模型,测定其一氧化氮(硝酸还原酶法)和内皮素-1(ELISA法)分泌量的变化。EGb761能显著性提高RMMMVECsNO和ET-1的分泌量,且NO/ET-1值没有显著性变化。
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关 键 词: | 银杏叶提取物 大鼠 心肌膜微血管内皮细胞 内皮素-1 |
Effect of NO and ET-1 on the Myocardial Membrane Microvascular Cells in vitro by EGb761 |
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Authors: | Tian Qichao Zhang Tao Hu Ge Tian Lifang Mu Xiang Liu Changsong |
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Institution: | 1College of Animal Science and Technology, Sichuan Agricultural College, Yaan 625014; 2College of Veterinary Medicine, China Agricultural University, Beijing 100094; ~Depanment of Animal Science and Technology, Beijing A gricultural College, Beijing 1022 |
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Abstract: | To study the influence of EGb761 on the secretion of NO and ET-1 in microvascular endothelial cells.Using the model of rat myocardium microvascular endothelial cells(RMMMVECs)in vitro,the secretions of NO by the means of nitrate reductase and ET-1 by the means of ELISA were determined.EGb761 could enhance the secretion of NO and ET-1 in RMMMVECs,and the ratio of NO and ET-1 was hardly changed. |
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