The evaluation of an experimental porcine herpesvirus 1 (Aujeszky's disease virus) subunit vaccine in mice |
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Authors: | D.L. Rock D.E. Reed |
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Affiliation: | Department of Immunobiology, Veterinary Medical Research Institute, Iowa State University, Ames, Iowa 50011 U.S.A. |
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Abstract: | Porcine herpesvirus 1 (PHV-1) antigens were extracted from virus-infected cells using the nonionic detergent Triton X-100. A single vaccination with these viral antigens in Freund's incomplete adjuvant resulted in the production of neutralizing antibody and a cellular immune response in mice. An 87% rate of protection was observed in these mice upon challenge with a lethal dose of PHV-1. A second vaccination given at day 21 resulted in higher levels of neutrilizing antibody and 100% protection of vaccinated mice upon challenge with virulent PHV-1. |
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