The expression pattern of TIR8 is conserved among vertebrates |
| |
Authors: | Federica Riva Nadia Polentarutti Giulia Tribbioli Alberto Mantovani Cecilia Garlanda Lauretta Turin |
| |
Affiliation: | aDipartimento di Patologia Animale, Igiene e Sanità Pubblica Veterinaria, Università di Milano, Via Caloria 10, 20133 Milano, Italy;bIstituto Clinico Humanitas, via Manzoni 113, 20089 Rozzano (MI), Italy;cDipartimento di Medicina Traslazionale, Università di Milano, Via Manzoni 56, 20089 Rozzano (Milano), Italy |
| |
Abstract: | IL-1R/TLRs play an important role in the inflammatory responses. Their signaling pathway is tightly regulated to keep inflammation under control. The regulation involves both extracellular and intracellular mechanisms. TIR8, also known as SIGIRR (Single Immunoglobulin IL-1R-Related molecule), is an orphan receptor belonging to the IL-1R/TLRs super-family. Recent studies suggest its role in modulating the inflammatory response in the gastrointestinal tract in mice, acting as an IL-1 receptor family antagonist. We identified the sequence and analyzed the expression of TIR8 in a wide panel of organs and tissues in different animals. There was high homology of the cDNA sequence among human, mouse and the domestic species (74–85%). The pattern of expression of this receptor was similar in all the species examined (high levels in kidney and gastrointestinal tract) and similar to the human. These results demonstrate that TIR8 is conserved, in evolutionary terms, both with regard to sequence and pattern of expression, a finding consistent with a key function of this molecule in modulating inflammation in the gastrointestinal tract. |
| |
Keywords: | TIR8/SIGIRR Inflammation Colitis Domestic animals |
本文献已被 ScienceDirect 等数据库收录! |
|