Concentration of cephalothin in body fluids and tissue samples of
Thoroughbred horses |
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| Authors: | Taisuke KURODA Yohei MINAMIJIMA Hidekazu NIWA Hiroshi MITA Norihisa TAMURA Kentaro FUKUDA Atsutoshi KUWANO Fumio SATO |
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| Affiliation: | 1. Clinical Veterinary Medicine Division, Equine Research Institute, Japan Racing Association, Tochigi 329-0412, Japan ; 2. Laboratory of Racing Chemistry, Tochigi 320-0851, Japan ; 3. Microbiology Division, Equine Research Institute, Japan Racing Association, Tochigi 329-0412, Japan |
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| Abstract: | Cephalothin (CET) concentrations in body fluids (plasma, synovial fluid, pleural fluid, peritoneal fluid, and aqueous humor) and tissue samples (bone, lung, jejunum, hoof, and subcutaneous tissue) were investigated to consider the treatment of infectious diseases in horses. CET 22 mg/kg body weight was intravenously administered to 12 horses. Samples were collected from four different horses at 1, 3, and 5 hr after administration. The CET concentration in body fluids other than aqueous humor was maintained above the MIC90 values of Streptococcus zooepidemicus and Staphylococcus aureus until 5 hr, but it was not maintained above that of S. aureus in bone. CET (22 mg/kg twice a day) is effective for septic arthritis, pleuritis, and peritonitis caused by gram-positive bacteria but ineffective for osteomyelitis. |
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| Keywords: | body fluid cephalosporins pharmacokinetics tissue |
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