Blood concentrations of 2,3-butanedione monoxime and some blood biochemical changes inbubalus bubalis after intramuscular administration of this cholinesterase reactivator |
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Authors: | J K Malik A K Srivastava |
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Institution: | (1) Department of Pharmacology, College of Veterinary Science, Punjab Agricultural University, 141 004 Ludhiana, India |
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Abstract: | The blood levels of cholinesterase reactivator 2,3-butanedione monoxime were determined in buffalo calves following single intramuscular doses of 20 and 50 mg/kg body weight. Blood cholinesterases and other enzymatic activities were monitored at various times. The drug was rapidly absorbed with half-life of 0.09–0.12 h. The peak 2,3-butanedione monoxime blood concentrations of 24.7±0.3 and 38.9±1.7 ug/ml occurred at 10 min after 20 and 50 mg/kg doses, respectively. The elimination half-life varied between 3.05±0.12 and 3.80±0.19 h. Lack of adverse effect of 2,3-butanedione monoxime on blood cholinesterases and other enzymes indicated that intramuscular doses as high as 50 mg/kg may be safely employed in buffaloes. |
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