A metastatic secretory gastric plasmacytoma with aberrant CD3 expression in a dog |
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| Authors: | Matthew J. Atherton Samantha Vazquez‐Sanmartin Sam Sharpe Elspeth M. Waugh Joanna S. Morris |
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| Affiliation: | 1. Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada;2. Oncology Unit, Animal Health Trust, Newmarket, UK;3. Diagnostic Services Unit, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada;4. College of Medical, Veterinary and Life Sciences, University of Glasgow, Scotland, UK |
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| Abstract: | A 10‐year‐old crossbred dog was presented with a 6‐week history of hematemesis, melena, anorexia, and lethargy. Clinical evaluation revealed a gastric mass with a regional lymphadenomegaly as well as a monoclonal gammopathy manifesting as hyperglobulinemia. Cytologic and histopathologic analyses were consistent with a round cell neoplasm; neoplastic cells showed nuclear immunoreactivity for MUM1 and diffuse cytoplasmic reactivity for CD3. Polymerase chain reactions performed on fixed and fresh tissue identified a clonal rearrangement with an IgH primer set. An extramedullary plasmacytoma (EMP) was confirmed by cellular morphology and molecular diagnostics. Following an objective response to chemotherapy, the dog was euthanized 8 months after diagnosis, and a postmortem examination confirmed the clinical findings. This is the first reported case of a monoclonal gammopathy secondary to a gastric EMP coupled with aberrant expression of CD3 in an aggressive plasmacytic tumor, and highlights the utility of molecular diagnostics for classifying atypical hemolymphoid neoplasms. |
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| Keywords: | Atypical immunophenotype
PCR
plasmacytic tumor |
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